Construction of a Growing Information-Community for Teratogenic Agents

Aiko YAMAUCHIa*, Eiko NAKATA DOOLINb and Hiroshi CHUMANc

aDepartment of Pharmaceutical Information Science, Graduate School of Pharmaceutical Science, The University of Tokushima
1-78, Sho-machi, Tokushima 770-8505, Japan
bDepartment of Pharmacy, NTT-East Kanto Medical Center
5-9-22, Higashi-Gotanda, Shinagawa-ku, Tokyo 141-0022, Japan
cDivision of Analytical Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima
1-78, Sho-machi, Tokushima 770-8505, Japan

(Received: June 6, 2003; Accepted for publication: June 30, 2003; Published on Web: August 26, 2003)

Congenital malformations or birth defects are a major public concern. However, lack of proper information may panic a pregnant woman who had taken medicines without noticing the pregnancy, and thus may result in an unnecessary abortion. We have undertaken a new research/development project to create an information-community for teratogenic agents, consisting of pregnant women, pharmacists, physicians and research scientists working on medicinal products. We have designed a trial database system for teratogenic agents. The database performs not only retrieval of teratogenic information and chemical structures of drugs/medicinal products, but also registration of clinical case reports and teratogenic information on various chemicals. Our system will be useful for clinical risk-assessment of teratogenic exposures in pregnant women and for the development of new drugs based on chemical information and computer science.

Keywords: Information-community, Bi-directional database system, Pregnancy and teratogenic agents, Medicinal products, Computational chemistry, Clinical QSAR


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