Computer Simulation of Hydrodynamic Models for Chemical/Pharmaco-Kinetics

Setsuro SUGATA* and Yoshihiro ABE

Kyoritsu College of Pharmacy
Shibakoen 1-5-30, Minato-ku, Tokyo 105-8512, Japan

(Received: August 21, 2000; Accepted for publication: September 29, 2000; Published on Web: November 20, 2000)

Six hydrodynamic models of typical linear chemical/pharmaco-kinetics (one containing a zero-order process) were simulated easily and realistically by computer. In particular, the pharmacokinetic simulation of a two-compartment open model with rapid intravenous injection provided many suggestions. The computer simulations were exact, and they could represent flow rate (kinetic velocity) exactly. Furthermore, the simulations could simultaneously show ordinary graphs of the variations in drug amount/concentration versus time. Therefore, they are superior to the actual hydrodynamic models in studying chemical/pharmaco-kinetics.

Keywords: Chemical kinetics, Pharmacokinetics, Hydrodynamic model, Computer simulation

Abstract in Japanese

Text in English

PDF file(134KB)

Author Index
Keyword Index